Beilstein J. Org. Chem.2019,15, 2213–2270, doi:10.3762/bjoc.15.218
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Keywords: catalysis; C-RFbond; fluorination; fluoroalkylation; transition metals; Introduction
Compared with other halogens (Cl, Br, I), fluorine (F) has completely different physical and chemical properties, such as a unique electronic structure, strongest electronegativity, and small atomic radius
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Graphical Abstract
Scheme 1:
The main three strategies of fluorination: nucleophilic, electrophilic and radical fluorination.